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For those with experience in magic mushrooms, is it better to take psilocybin with ssri or stop it before for better results treating major depression disorder?
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I'm 28 yo suffering from depression since 8 years, in about 6 months ago i was able to put my hands on magic mushrooms, i was on 100mg of Zoloft and 200mg of quetiapin, of course i stopped the quetiapin for 1 week before I try the magic mushrooms and remained on 50mg of zoloft, i took 3 doses for 3 days, the experience was incredible, i could feel that I'm alive for the first time since 8 years, but after the 3 days over the depression was not over with it, although i was a bit more stable for like 2 months and then collapsed again.

Now after 6 months I'm on 50mg of Zoloft and going to travel to an island to try magic mushrooms again, this time i will take it daily for 7 days and i will take high doses, because the doses i tried before weren't Hallucinogen, so the question is, is it better from your experience to stop the ssri before i start taking the mushrooms and see how it's going to work this time? I'm afraid that the ssri might has weakened it's effect the last time or maybe blocked it a little bit. Now I'm very deprressed and my only choices are to get back on quetiapin or try magic mushrooms again, but this time i want to do it properly.

Note* I'm going to stop the ssri today and i will travel after 7 days, so i will be 7 days free of Zoloft only when I take the mushrooms.

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6 months ago