I am a private practice family physician not affiliated with any institution. I cannot and will not be able to do "human trials" the most I am allowed to publish legally is a case series, which is a maximum of 3 humans. I can describe what happened to those 3 specific humans, but I cannot do any sort of "trial" only retrospective case reports.

The amount of idiots saying, "Where is the double blind peer reviewed research?!?!?" is astounding. People literally do not understand that costs millions of dollars, huge institutions and IRB's.

Regardless, here is a publication I put out last year, peer reviewed and everything!

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https://clinmedjournals.org/articles/jcgt/journal-of-clinical-gastroenterology-and-treatment-jcgt-8-086.php?jid=jcgt

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This patient was dying a few years ago of short gut syndrome. She pooped about 16 times a day while awake and was unable to absorb food or medication due to this. She was on so many anti-diarrheals that did not work, and had to starve herself to even leave her house. She asked me to help her with medically assisted suicide. I decided to use a drug from my HIV knowledge (I'm a certified HIV specialist) off label to try and treat her. She agreed that she would try it, but if it didn't work, she would commit suicide rather than continue to suffer and starve to death.

It did work, it worked so well that she was able to regain nearly 60 lbs, and now poops once to twice daily at the maximum. This was not an "authorized on label" use of this drug. It is intended for HIV patients which she was not. She was literally going to die, and now, she has returned to her normal life, and this publication was used by the drug company who makes it to justify a request to do the double blind placebo controlled trial you always demand from me that will allow it to be used on label for the treatment of short bowel syndrome.

In short, my publication on my "experimental" off label usage of this drug has now started a literal globally enrolling trial to prove it works like I say it does to get EU and FDA approval for this to be used on label and covered by insurance for probably a million people worldwide.

So before you attack me, understand, trials and science start in a small family practice when one guy does something for one person. This is a true story, and the evidence is right here. Please stop harassing me about not publishing "peer reviewed" articles as I already have, as this was clearly a huge priority over progesterone up the butt. The fact is, I cannot run these expensive human double blind trials. I can only do the case reports which result in these investigations, something I've already done.

I am working on case reports now as a series for Meyer-Powers Syndrome

Here are proof of the upcoming trials based on my publication, I have been working with Napo directly about this since almost 3 years ago:

https://jaguar.health/pipeline/crofelemer-in-intestinal-failure/

https://www.biospace.com/article/releases/jaguar-health-provides-updates-on-presentation-at-the-world-congress-of-gastroenterology-about-crofelemer-for-pediatric-short-bowel-syndrome-sbs-and-congenital-diarrheal-disorders-cdd-by-third-party-investigator/

This is literally all I can do. I am tired of arguing with people about my lack of "peer reviewed" research, so from now on, I'm just going to link them my publications that have already resulted in clinical trials, trials not done by me, but started by work I did with boots on the ground in a small office in Farmington Hills, Michigan.