We theorized that this might be possible with people with less severe dysphoria. I have definitely seen it work in children before but this is the first time it's happened in an adult.

The patient has been on estrogen for over a year, this was beneficial to them for dysphoria, however they decided to stop it temporarily due to an infection and the high risk of blood clot.

After doing this, they no longer felt dysphoria.

This is the first anecdote of this happening even though it was theoretically plausible based on the theory of Meyer-Powers syndrome. Rarely do I have my transgender patients go off HRT to try this, in fact, it's never happened, as this is the first time it happened and it wasn't to try this. It was just by accident.

Regardless, I wanted to put this out there, and the patient has multiple known MTHFR defects. I will continue to report if we have more evidence of this with further cases. I don't think that this is going to be a panacea for gender dysphoria, but similarly to how I have seen some of my lesbian patients shift to bisexuality with treatment, this may be an option for someone who feels sort of non-binary or has only mild gender dysphoria. No lesbians have become straight so far, but there has been a notable change in orientation in many of them. I think this will be much the same in that there may be some shifting of gender identity if the patient undergoes treatment while not on HRT, I doubt that someone with severe dysphoria will suddenly feel nothing when the methylation defects are treated.

Edit: I understand that people might be offended by this. That being said, I'm going to put out my theories here as always, this is where I put my theories. I do this so I can collect more information from other people. Because if someone else decides to do this here, and gets the same result, that would be interesting to know.

I am not linked to some academic university and I do not have the resources or funds to do some sort of massive study. This isn't possible. So when something unusual happens like this, I remark on it so that people have the opportunity to be aware of it. Maybe it is a complete fluke, but maybe not. Regardless, this is not meant to offend anyone or to make anyone feel uncomfortable or to claim some sort of eugenics fix for gender dysphoria. I'm only putting it out there because if someone else has a similar experience I would want to know.

I am trying very hard to understand why so many of these genetic mutations occur in this population, why so many of them have the things associated with MPS. And what can be done to help them as much as possible. That is all I am ever trying to do, to help this population, and so please understand I do not mean anything negative by this. This is just what one adult patient experienced. I have already seen this happen multiple times in children pre HRT and I have remarked on that before.