“It struck him that in moments of crisis one is never fighting against an external enemy, but always against one’s own body. Even now, in spite of the gin, the dull ache in his belly made consecutive thought impossible. And it is the same, he perceived, in all seemingly heroic or tragic situations. On the battlefield, in the torture chamber, on a sinking ship, the issues that you are fighting for are always forgotten, because the body swells up until it fills the universe, and even when you are not paralysed by fright or screaming with pain, life is a moment-to-moment struggle against hunger or cold or sleeplessness, against a sour stomach or an aching tooth.”
Excerpt From: “1984.” iBooks. 

Do you ever regret doing something because you were paralyzed by inner thoughts or emotions that made you blind causing losing your sight? and if so how did you work on transcending these psychological or probably physiological limitations.