Hey all.

So, my clinic are super stumped by some strange issues I’ve got going on and have resorted to shoulder-shrugging. I’m hoping one of you guys has some insight.

In January I was taken off of Itraconizole. I’d had a few runs of fungal plugs, but my Aspergillus ige was too low to justify my staying on it.

Immediately after finishing it my health drop off. My lungs feel moderately clear (been on Ivacaftor since 2013), but some tightness and increased sputum. The main symptom was dizziness, weakness, and general feeling of malaise. I’d become dizzy when I stood up and would sometimes find myself having to grip walls or doors when feeling like I might lose consciousness (never did fully, but fell into a few walls). I started Trikafta/Kaftrio during this period, but it didn’t help.

A few weeks ago I did a fortnight stint in the ward on Meropenem & Tobramycin, with Aminophylline overnight. No change whatsoever until my last dose of Meropenem when I felt a strange burning sensation just over my upper abdomen on the right (near bottom of rib cage). It lasted a couple of minutes then went away. Shortly after I had a burning pain in my right shoulder which stuck around for like 3-4 hours. ECG and BP fine.

Shoulder pain was quite bad. It came and went over the next week, then on day 8 it came back big! 7/10 pain for hours. Prior to this I was still experiencing the malaise, then the day after this bad pain my dizziness disappeared completely. One thing to add, after the bouts of pain my urine had a strange sickly sweet smell.

My Drs have no clue whatsoever as to what happened. I’ve been under investigation for heart issues and had CTs and a Echocardiogram, but nothing came back. My heart rate is higher than it’s ever been (resting gone to mid-60s from late-50s for last few months (Fitbit)), but they don’t seem concerned. Bloods don’t show anything irregular. They’re disregarding the upper abdomen pain as a red-herring, but that’s seems strange to me as they’re clearly linked.

Anyone had anything similar? I’m in clinic later today, so anything to take in with me to suggest would be great.