Hello I'm bipolar type 1 with particular issues with clinical depression. I've been through an array of medications and my current regime of 20mg of vortioxitine and latuda 34mg isn't working as I've had breakthrough depression. We tried to increase latuda but I got akathasia/restless legs syndrome that was unbearable. I've now been given some options for new treatments and wanted to know if you've had any experience on these new medications I've been offered. One thing to note is that I'm obese and prone to weight gain, sweating and becoming prediabetic so that's something to keep in mind. Any and all thoughts are welcome.

new possible meds as follows: lamotragine quetiapine lithium aglomelatine duoxotine