I am an Internal Medicine Physician and I am interested in longevity medicine and critical appraisal of scientific literature. I was doing practice questions for board exams using a popular question bank (MKSAP) and I came upon a question in which a 65yo male is has common medical conditions and taking multiple supplements in addition to some medications and they ask what you should recommend regarding his supplement use. And the answer was "Stop all supplements" & learning objective was "Dietary supplements have questionable efficacy in improving health, and their use is associated with risk for both direct and indirect harms. In general, there is little good-quality evidence showing the efficacy of dietary supplementation, and use carries the potential for harm."

It is so frustrating that we are taught to have this blanket response to supplement use. "Little good-quality evidence" is not the same thing as "evidence does not suggest benefit". The absence of evidence does not suggest the absence of benefit.