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So, in Canada it would seem that the only supplier of Oxaloacetate costs about $600 for 90 500 mg capsules. Recent trials has been completed showing positive results for Alzheimer's and Chronic Fatigue at a dose of 1 - 2 g a day. So, the monthly price point is a bit outrageous.
It's my understanding that most consumer suppliers use sodium oxaloacetate (stabilized oxaloacetate, CβHβNaOβ ).
But technically there is also Diethyl Oxaloacetate Sodium Salt (CβHββNaOβ ), which seems very similar. There seem to be no direct references or studies on it as an ingested substance. However, it is not corrosive in this form (as compared to pure oxaloacetate). Is Diethyl oxaloacetate sodium salt theoretically more suitable as an oral supplement due to its higher lipophilicity? Other than this, it seems very similar to sodium oxaloacetate.
I'm a bit nervous about that because Diethyl oxaloacetate does have two additional ethyl groups, the reactions of which haven't been studied as a supplement. These groups increase the fat solubility (lipophilicity), which should actually enhance absorption through the intestines. Similar supplements that also contain ethyl esters include fish oil and aspirin.
In powder form it can be stabilized using ascorbic acid at a ratio of .1 to 1% simply by combining the powders and storing in an air tight container.
Some bulk suppliers can provide 50g of Diethyl Oxaloacetate for only $100 or so plus shipping. Could I mix .5mg of powdered vitamin c/ascorbic acid with 50g of diethyl oxaloacetate and then simply take 1g a day?
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