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https://www.allure.com/story/ozempics-effects-on-skin

While operating on Ozempic patients, Dr. Few started to notice a trend: The skin quality of someone on a GLP-1 was reminding him of an “old, overused rubber band.” Mark Mofid, MD, a board-certified facial plastic surgeon in San Diego and La Jolla, makes a similar comparison—it’s like the elastic waistband on a pair of underwear that has stretched out over time.

Dr. Diamond, who specializes in facelift surgeries, has noticed the SMAS layer is “definitely thinner and weaker” on people who have been using GLP-1s for weight loss. (SMAS is an acronym for subcutaneous musculoaponeurotic system, a layer of connective tissues that supports the face.) Usually, the SMAS thins naturally as you get older, which can contribute to facial aging, like sagging around the cheeks, according to a study published in Aesthetic Surgery Journal Open Forum. And if an Ozempic patient has plans to become a facelift patient, it’s worth noting that the SMAS layer is also essential for natural-looking results. “The success of the facelift is really based on the strength of the muscle layer,” says Dr. Diamond. “You’re not pulling out the skin and using that to get the lift. The muscle layer being thin can definitely affect facelift results.”