I've been deep diving this issue recently as I have low neurotransmitter synthesis coupled with slow MAOA, MOAB and COMT.

My plan of attack has been to bypass synthesis issues with L-Dopa and 5HTP, which has worked really well but can be quite complicated to various interacting pathways.

So, in line with the old adage of "less is more" I'm considering slowing my MAOA and MAOB further in order to extend the life of neurotransmitters in the synaptic cleft.

Taking PEA as an example, for normal metabolizers, this has an extremely short life span, and inhibitors are needed to make useful.

Whereas us slowbies can, in theory, benefit for hours with no extra help.

Slowing MAO's down further would then theoretically extend the life and help to support impaired synthesis, too.

I realise that running on low baseline levels of neurotransmitters isn't ideal, but in theory, inhibiting things further would have a similar effect to supplementing extra L-Dopa or 5HTP.

Has anyone gone down this path, and what success (or failure) did you have?