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I've tried NAC 3 times. Every time, I've experienced unbearable back pain.
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NAC was a life-changer for me. I had long covid and taking NAC for only 2 or 3 weeks greatly improved my symptoms.

For some extra background: I have a degenerative disc disease in my lower spine. It began when I was 17 inexplicably. There's never been any explanation, no treatment of any kind helped. I was able to mitigate most of the symptoms and eliminate virtually all of the pain through weight lifting and other exercise.

Anyways, after about the first week or so of taking NAC, I developed crippling back spasms and weakness. It was insanely painful, I could barely get up and I couldn't lift anything.

I didn't think it had anything to do with the NAC. I had taken a break from the NAC after a few weeks just due to a gut feeling. My back started to get better.

When I tried to start up the NAC again, my back became weak and started spasming again.

A few months later, I decided to take just a few doses of NAC... I frankly can't remember why. But my back was crippled for another week or so after.

Every time, the back problems come on very slowly. It takes at least a couple of says for the pain and weakness to really kick in.

Has anybody ever heard of anything like this? Or gave any idea why this would happen? It seems insanely weird to me but after 3 times I can't deny it's a real reaction.

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6 months ago