Hello. I do not know whether I should post this here or in /r/molecularbiology but here goes.

I'm a current undergraduate student studying Medical Technology and my thesis is about the possible effect of depolarizing cells with toxins against the binding of saxitoxin. While most of our methodologies are in place, my groupmates and I(mostly I and a friend) still do not have any way to measure if there are any significant effects of delaying the binding of saxitoxin against it ; the only way we are currently deciding on measuring it is through the following

• Na-K levels in blood
• Death time

Neither of which I am actually convinced to have a good representation of the effects of depolarization on saxitoxin poisoning.

Finally, a thought came up to me recently and as a result, I am now looking for the end-product of saxitoxin-catabolism and see if we can use it as a way to measure the effects of depolarization inhibition.

I know this isn't much to go on nor is it the smartest of theses(personally, I think this is now a hodge-podge of things) but it's still something I want to perfect even if we may end up not doing it because of time restraints(goshdarnit university deadlines!).

If anyone has any idea on this OR if anyone has a more feasible/reliable way on discerning if depolarization has any effect on saxitoxin-binding/lethality, I would gladly take suggestions and criticisms!