I wanted to share with you some info on the Goetz trial a few years ago and some of my findings.

I started thinking about the Goetz trial when Quay recently announced that they would show MRI scans of before and after taking Endoxifen on the upcoming medical conference. I thought that was remarkable, since that was not described in the clinical trial, and since I remembered that Goetz did the same thing in his trial. (Picture 1)

So I looked up the pharmacokinetics of Goetz's trial. From 20mg to 160mg... Remarkable, because in the MRI scan picture, they used 160mg Z-Endoxifen. And that got me thinking.

In 2017 Goetz was using normal capsules Z Endoxifen, provided by the NCI. So NOT the enteric capsules that we have a patent on. Very important because without those enteric capsules, Quay said, that 50% or more of Z Endoxifen is converted into INACTIVE E-Endoxifen by the gastric acid.

So I message Eric, to ask if we are indeed using Enteric capsules allready. He confirmed. Yes , we do.

If Goetz had (picture 1) such a anti tumor effect by using 160 mg Endoxifen, where at least 50% was converted in E-Endoxifen by the gastric acid... I am sure, we will reach similar, if not better, results, and thus MRI scans, with the 80mg PK Cohort study.

Now imagine that we can publish a similar MRI scan in a few weeks/months on a medical conference. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648176/

https://preview.redd.it/0ao4sqog9unb1.jpg?width=832&format=pjpg&auto=webp&s=b0b18853a96e09ad333f92c392d308d2904c3e29