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Does an altered cholinesterase gene affect recreational drug use?
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The following seems to indicate an increased sensitivity to alkaloids...

"Atypical" BChE has a low affinity for CI alkaloids naturally occuring in certain plants, particularly those in the nightshade family (potato, tomato, peppers, eggplant, etc.). rs1799807(G) carriers may be more prone to physiological consequences of AChE inhibition from eating these foods.

This seems to indicate that some recreational drugs get their effect from alkaloids...

https://cen.acs.org/articles/94/i23/Recreational-drug-kratom-hits-same.html

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7 years ago