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Could my acne cream treatment be causing sexual side effects?
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22 year old Male 67kg Occassional smoker

Hi all, I am currently using a treatment for my acne called Azelaic Acid (20%).

I am concerned that it might be causing some side effects in me such as loss of libido, abililty to get an erection and general low mood.

I know that the cream is a DHT blocker and although it is applied to the skin, it seems it can be absorbed into the bloodstream and become systemic aswell. I worry that is impacting my hormones (levels of DHT) internally. And apparently this is the side effects of DHT blockers.

I found this article that says that absorption of topically applied azelaic acid is 3.6% of the total dose. It also shows 2.2% excretion in the urine.

https://www.deepdyve.com/lp/wiley/percutaneous-absorption-of-azelaic-acid-in-humans-XWdS4b3B7L?

I don't really know what this means. Is that enough to actually impact hormones? Even if the azelaic acid is absorbed, does it actually have any impact?

I am kind freaking out about this and I don't know whether the side effects are real or in my head/due to anxiety. It just seems crazy to me that a cream I apply on my face could impact me internally, but could it?

Thanks

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4 years ago