Personally, I've sometimes noticed a paradoxical increase in heart rate and blood pressure as the (stimulant) medication wears off. I'm thinking it might be due to my anxiety coming back... potentially also some sort of 'rebound effect' making anxiety symptoms stronger as the medication wears off.

Like many of you (from what I've read) I experience a calming effect as the medication kicks in...

I've been monitoring these things, both as a precaution (given that stimulants tend to have a mild effect in increasing heart rate / bp) and to gauge the onset and duration of effect of the medication.

Today I took meds (IR dex) 10mg coffee about 9 hours ago, another 10mg at 7 hours ago, and 5mg 5 hours ago. Yet my heart rate and blood pressure are pretty much the highest they've been all day, while I feel increasingly restless (as expected).

Usually if I take one isolated dose, the effects will have started to fade after about 4 hours and I have a tendency to crash back down to my usual self by around 6 hours. And caffeine (which I don't have every day to avoid tolerance) has a shorter half-life than dex.

Curious if this is something anyone else has noticed or experienced. I'm mostly inattentive subtype with some co-morbid anxiety and mild depression, for what it's worth.

edit: from the research I've done, it seems that your body develops short-term tolerance (i.e. during the day) to the benefits of the medication, but not to the cardiovascular effects (see journal article here and my comments here). This explains a lot!