Okay, so full disclosure, my cat, Corvus, has terrible allergies. After tons of exclusion diets and testing, we finally figured out he has an allergy to dust mites (to which is pretty much impossible to prevent exposure). He's on cyclosporine and apoquel, and he gets allergy shots for this as well, and he's still only about 50% better. The vet says "sorry, there is nothing more we can do".

As always, that's sort of a call for me to start tinkering, and so I went down the rabbit hole of peptides a few months back. I found a company that would make me peptides at very high quality to my specifications, and I ordered a multitude of different things (aside from some things to help Corvus).

One of these peptides was PT-141, aka Bremelanotide, or also known commercially as "Vylessi", an injectable medication FDA approved to boost libido and sexual function in women.

The drug is astronomically expensive:

https://www.goodrx.com/vyleesi

This is the drug:

https://en.wikipedia.org/wiki/Bremelanotide

Also, the side effect profile is terrible. I used it on myself, and while I will admit I was probably more "libidinous" than I've ever been in my whole life, I was nauseated, felt like I had the flu with body aches, and it was fairly miserable. I kind of felt how I felt after getting the covid vaccination for the third time.

I suspected the reason for a lot of the side effects was my body recognizing the amino acid based molecule (its 6 aminos in a ring) as a foreign protein, and thereby mounting an immune response against it.

I wondered if I absorbed it at a mucus membrane if the immune response would be less, and also could I get more positive effects and less side effect.

So I made myself a nasal spray bottle liquid suspension of the peptide, and well, gave it a whirl.

To my pleasant surprise, the side effects seem to be fully eliminated, yet the positive effects of the drug remain.

I still need to mess around with it a bit more to calibrate dosing to efficacy vs cost, but I was able to source some FDA approved reagent to be able to compound my own intranasal sprays of this and offer it to my patients (where appropriate and safe).

Fairly soon, this will be available from Superior Compounding to patients of PFM.

Incidentally, the drug can cause a lot of neat sexual function changes such as elimination of refractory period, multi-orgasm, powerful erections, and more. Its not just the increased libido, the whole sexual system basically goes into overdrive.

I'll post again when its available for RX. But I expect it to be ready within a few weeks. As far as I'm aware, there is no drug out there that will both simultaneously increase libido and sexual function in women with a very tolerable side effect profile like this, and I've managed to do it at considerably less than 7 grand for 9 doses, so I suspect this will be immensely popular when its ready. Commercially it seems to be about $1000 per "use" and I'm hoping to get the price point for this down about 99% off to somewhere around $10 per "use" which I think will be accessible to most people in the practice.

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EDIT: I ignored one side effect which is still present and forgot to comment it. The uncontrollable need to stretch, which feels amazing. I can't really describe it any other way than you just feel like you need to stretch your muscles, and when you do, its awesome. But then you keep feeling like you need to keep stretching. Its truly strange.

As of yet I have not noted any hyperpigmentation side effects (the injectable one can basically give you a tan without sun exposure if used too much) but I will continue to monitor it. The molecule isn't too distant from melanotan.