Actively working on the paper, but so far, I continue to get back positive MTHFR mutations in my transgender patients at a rate that's just astounding.

I myself have a bunch of components of the 6p21 syndrome (pinned post on the top of the sub), And I ran a full genomic sequencing on myself.

Wouldn't you know it, I have two bad copies of the MTHFR gene.

I immediately started myself on L-Methylfolate and Methylcobalamin.

Within 7 days, my mental health improved considerably, my Adderall works way better than it did for years, and I have a decreased need for sleep and overall sense of wellness. It had a large impact on my brain. I don't know where else it's going to show up in my body and give me some sort of benefit but this was readily apparent at the beginning.

Considering that I have so many transgender people that I've tested so far and nearly every single one has this mutation (seems about 98% come back positive) I'm going to make the suggestion that if you have the ability, get tested for this if you have gender dysphoria.

There is an additional benefit if you have it, because you will not be aware of the fact that you have an elevated homocysteine.

I recently had a non-binary/gender non-conforming AFAB patient with autism and ADHD that I saw for a physical. I ordered the lab on her because she fit many of the criteria of my "syndrome". Came back positive, and not only positive, her homocysteine value was over 160.

A normal value is about 10 or less. Without getting too much into the details, the best way I can describe homocysteine is sort of a spiked morning star like metal ball that just bounces around inside of your arteries and runs into LDL particles and pops them open and spreads that grease all over the inside. (That is a gross over simplification but it gets the point across)

This young person was walking around with a astronomically high inflammatory protein in their blood and they had no idea. Simply taking a special vitamin fixes it.

If you don't have the ability to get the blood test to confirm whether or not you have the mutation, you could try this if you wish by simply ordering the vitamins on Amazon and giving it a go for a month.

That being said, for the friend I mentioned previously with type 3 EDS that got better? It took nearly 6 months for those effects to show up. Her defect wasn't in sex hormone synthesis, it was in collagen synthesis, and so it took that long for collagen turnover to be laid down better and for her to perceive the difference. It was not instant.

Your mileage may vary, but if you end up looking at that list of 6p21 stuff and you think "wow I've got a lot of these" I would suggest either getting tested or trying the vitamin as a trial. It's pretty cheap, and in good conscience, I can't continue to keep this a secret as I work on the paper because I genuinely think this is going to help a lot of people.

I do have a theory that if given early enough in life, treatment with this may actually resolve gender dysphoria and people who are having a mild enzymatic sex hormone synthesis mutation amplified by this other mutation. I'm not sure yet, I've not been doing this long enough to see whether that affects anybody or not. I also have no idea at what point it would stop working or if it even works at all. But if somebody does try this, and their gender dysphoria spontaneously resolves, please do let me know. I'm actively collecting as much data on this right now as I can as I unravel the genetics behind it. Thankfully, I have some help, and a very very intelligent woman who helped me put the pieces together and make sense of all of the correlations I was seeing has been absolutely astoundingly supportive as we go through the process of trying to make this thing real and get it published.

As a side note, the two publications I've recently submitted with other doctors are currently in review and I am hoping they will be approved soon for publication. As soon as they are, I will link them here. I'm really looking forward to seeing the fertility restoration paper be out there in the world.